K. F. Nimoh1*, F.C. Mills- Robertson1, B. O. Afranie1,3, J. Taylor1,2, S. Donkor1,3, S. Nsiah4
1Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science &Technology, Kumasi, Ghana.
2Department of Pathology, School of Medical Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
3Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
4Department of Nursing, Faculty of Health and Allied Sciences, Garden City University College, Kumasi, Ghana.
Received 24 September 2017; Accepted 27 September 2017; Available online 28 September 2017
Abstract
Anaemia is a global health problem affecting people of all works of life. Anaemia has a lot of adverse effects hence the need for a cost effective and better treatment strategy. Ethnopharmacological information indicates the use of the combination of Coca-Cola drink and tomato paste to manage anaemia in Ghana. The study investigated the effect of the combination of Coca-Cola drink and tomato paste on haemoglobin levels using animal models. 20 male Wistar rats were grouped as normal, 2,4-DNPH only, Coca-Cola drink only (0.5 ml Coca-Cola drink/100 gm b. wt./day), tomato paste only (20 mg tomato paste/100 gm b. wt./day) and combination of Coca-Cola drink and tomato paste (0.5 ml Coca-Cola drink/100 gm b. wt./day and 20 mg tomato paste/100 gm b. wt./day) with 4 animals in each group. Animals in other groups apart from the normal group were injected with 2,4-DNPH consecutively for 7 days (2 mg/100 gm w.bt/day i.p,). Animals in 2,4-DNPH only group were sacrificed on the 8th day. All animals in the remaining groups were maintained till the 21st day. Body weight was significantly reduced (p˂0.05) in all groups with 2,4-DNPH injection in the first 7 days. From the 8th-21st day, body weight was significantly gained (p˂0.05) in the combination of Coca-Cola drink and tomato paste group. Haemoglobin concentration, red blood cell count and packed cell volume were not significantly reduced in the 2,4-DNPH only group. However, haemoglobin concentration, red blood cell count and packed cell volume were significantly increased (p˂0.05) in the tomato paste only group and in the combination of Coca-Cola drink and tomato paste group. Conclusively, a combination of Coca-Cola drink and tomato paste had a significant increase on the haemoglobin levels indicating some haematinic and anti-anaemic potential.
Keywords: Haemolytic anaemia, Haemoglobin concentration, red blood cell count, packed cell volume, Coca-Cola drink, Tomato paste.
Scientect Journal of Life Sciences (2017) 1 (1), 16-20
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